Week 12 is a weird one for running backs on bye. On the one hand, we're avoiding the headaches of the Chiefs and Cardinals backfields, two situations that have burned plenty of Fantasy players this season, most recently in Week 11. On the other hand, with the Vikings and Chargers on bye, we're also missing three must-start backs in Dalvin Cook, Austin Ekeler, and Melvin Gordon. It's not the worst week of byes we've had to deal with — it's tough at quarterback this week — but it still complicates things in the final week of byes.

What really makes Week 12 tough to navigate at running back, however, is situations like the Colts, Buccaneers, Steelers, Dolphins, Eagles, Lions, Patriots, and 49ers, where it just isn't clear in any given week who, if anyone, you can trust. Chances are, you'll have to trust at least one player from those backfields, and that might not be a full list of the teams with questions among their running backs. The elite running backs have been pretty great this season, but as injuries pile up, it gets tougher to trust the rest of the position every week.

It's going to be tough to figure out how to handle the running back position this week, but we can help. We've got Jamey Eisenberg's Start and Sit calls right here to help you make the right calls, plus Heath Cummings' running back preview has projections, matchups that matter, numbers to know, and more as you prepare to set your lineup. It's going to be a tough week at running back, but we're here to make sure you're setting a winning lineup for Week 12.